when you've been up for forever on meth and are starting to trip hardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you're hella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
This is a word often used to describe an individual (more specifically a lower-income female from the inner city) that is loud, tacky, boisterous, and not used to the finer things in life.
TaShaNe is truly a tackhead. She went to red lobster and asked in a loud ghetto voice for an order of "scrimp." After that, the tackhead asked "Do ya'll take EBT cards up in here."
Originated in Stillwater, Oklahoma in 2000. When you've done too much tweak to the point where you are useless to the world. When you are so spun that you are get caught in the same repetitive motion until you run out of crank.
Damn, Tamara's been working on that crossword book for 3 days straight, someone take her dope away, she's twacked the f&#^ out.