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Pick of Destiny 

noun
A green, skull-like guitar pick fasioned from one of Satans teeth. It granted the user supra-natural rock and roll abilities. Satan recently recovered this item, although he lost his right horn in the process. The horn was later shaped into a bong. The last owners of the PoD were Jack Black and Kyle Gass (Tenacious D).
I just bought Tenacious D in the Pick of Destiny on DVD. It is fuckin' hilarious.
Pick of Destiny by picolo592 March 21, 2007
Related Words

Pick Gnome

Pick Gnomes are devious abominations that spend their lives solely to do what they can to destroy the human race. The impact they have is great, by stealing any guitar or bass pick that hits the floor after accidently being dropped. Ever drop your guitar pick? yup the pick gnomes. It's gone buddy. GONE.
Fred-*shredding but drops pick*
Andrew-"Hey man, where'd your pick go? it should be like under your chair"
Fred-"DAMN YOU PICK GNOMES!"
Pick Gnome by wehrmachtalie January 16, 2009

pick me mom 

a pick me mom is a mom who uses self depreciation to make her children feel guilty, and pay attention to their mom more.
pick me mom: You don't appreciate anything I do for you! 🥺
child: *guilty noises*
pick me mom: I wish I had kids that actually appreciated me unlike you! 😓
pick me mom by bria2swaggy May 26, 2021

pick-me-up 

something to brighten your day or give you an energy boost, especially useful when you can't spare time for a lunch break during a long day of work.

also, chemical mood enhancers such as alcoholic beverages.
Let's go for coffee, I could sure use a pick-me-up.
pick-me-up by kiki86 April 9, 2007

pick that one out 

When the goalkeeper gets absolutely owned by a top bins screamer and is forced to 'pick that one out' of the net for kick off.
MATT: 'Top bins watch it' *Pelts it top bins* 'YEAH BILLY, PICK THAT ONE OUT'
BILLY: 'Okay... *Picks that one out*
pick that one out by Matt69lol November 25, 2016

Pick six 

A term used in football when a player of the defensive team intercepts the ball thrown by the quarterback of the offensive team and runs it back into the end zone for a 6 point touchdown. "Pick" is open to interpretation but is basically used for when the defensive player grabs the ball. The "six" is used to describe the six points earned from the touchdown.
"Did you see Kyle's pick six last night? It helped us win the game!"
Pick six by Brit Morgan October 22, 2013