something to brighten your day or give you an energy boost, especially useful when you can't spare time for a lunch break during a long day of work.

also, chemical mood enhancers such as alcoholic beverages.
Let's go for coffee, I could sure use a pick-me-up.
by kiki86 March 29, 2007
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something to keep you going whether if be an energy drink or a bump of some blow
i need a pick me up cuz i havnt done any shit for about an hour
by e-haw420 June 24, 2008
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A little some thing someone says or does to make a sucky day turn in to a good day.
friend 1 "There's no drama in my life, there's no drama in my life. repeat until haters go away"

Friend 2 " wow you just made me smile ! that was just the pick me up I needed "
by realgothy September 12, 2011
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When the person drinks coffee and French kisses someone, and the recipient tastes the coffee on the person's tongue.
"That person gave me quite the pick-me-up, I was able to taste the coffee right from his mouth!"
by SomeGuyFromBrooklyn July 30, 2017
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1. (noun) When someone seems down in the dumps, or simply unhappy, you make them feel better with sex.

2. (verb) The act of fucking a sad or depressed person to make them happy again.
Guy 1: She's pretty hot, but just seems so depressed. Sorta like Kristin Stewart in all of her movies.

Guy 2: Sounds like she needs a pick me up fuck.
by browin September 14, 2013
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1. Sex act where one partner stands on his/her head whilst the other kneels in front supporting the legs and performing oral copulation.

2. A place where Obama goes to be politically refreshed.
Barry and Michelle's sex life was a little boring until Michelle asked for and received a Brandenburg pick-me-up.
by Scoo0oop June 20, 2013
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Two Pringles Original Flavor chips with Reddi Wip whipped cream in the middle.
Jump-Rope Sally was pushing "Colbert pick-me-ups" behind the swing sets at recess, until Principal Sanders caught her with a Reddi Wip and an empty can of Pringles one day.
by Cottonsince85 March 30, 2010
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