Stuck on something that puzzles you, or does not make sense to you, so much that it messes with your mind;
Or
Messed, ratty, looking confused and unorganized
I'm just disfuzzled by your explanation, it's so ridiculous!
Or
What did you just roll out of bed? You look disfuzzled!
-"When he got in that motorcycle wreck, it completely disbuggled him."
-"I found out he has a VD, and now I'm all disbuggled."
-Lyrics from "93" by Elliot Drake: "Everything is muzzled. Everything's disbuggled. Everything's in a cage, oh lord I feel the rage, oh lord I feel the rage."