Variation of, "you are a liar" or "quit clowning". Indeginous to the American South, specfically Mississippi.
As Jimbo ends his "Yo Mama" joke ( directed towards Leroy), Leroy counters with, "You a lie."
by millhouse May 07, 2004
Get the mug
Get a you a lie mug for your coworker Vivek.
Something some students in Washington say when a friend, family member, etc tells a lie.

Roots: "You a Lie" is used most frequently, and was brought up from the TV show "Meet the Browns."
Josh: So what did you do in Arizona?

Jacob: I invented the teleportation device.

Josh: YOU A LIE!
by JPdude6 April 09, 2010
Get the mug
Get a You a Lie mug for your mama Beatrix.
The classiest way to respond to anyone you disagree with.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by illicit_fun_owns September 09, 2009
Get the mug
Get a You lie! mug for your friend Rihanna.
What Leonardo shouted at Shredder when Shredder claimed that Splinter was dead.
Raphael: Where's Splinter?

Shredder: Ah, the rat. So it has a name. It had a name.

Leonardo: You lie!

Example 2:

jorgorthebarbarian: "You lie!" is what Michaelangelo shouted at Shredder when he claimed that Splinter was dead.

Me: You lie!
by shouldn't have apologized wuss September 27, 2009
Get the mug
Get a You lie! mug for your Uncle Jerry.
What Michelangelo shouted at Shredder when Shredder claims that Splinter is dead.
"You lie!"

"Do I?"
by jorgorthebarbarian September 10, 2009
Get the mug
Get a You lie! mug for your buddy Manley.
The (obviously) most classy way of politely telling someone that they are wrong. Take it from Joe.
Obama: I like pie.

Joe: YOU LIE!
by jazjaz130 September 11, 2009
Get the mug
Get a You Lie! mug for your Facebook friend Sarah.
The easiest way to object to a statement for which you have no legitimate argument.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by stating the obvious September 13, 2009
Get the mug
Get a You lie! mug for your buddy Georges.