x's and o's bitch Share definition Flag Something that is said to close out a letter, IM, or really any conversation... Audrey, stop whining and get back in the game, x's and o's bitch. x's and o's bitch by AF of Des Moines March 4, 2010 0 0 Get merch Get the x's and o's bitch mug. Buy Now — $32.95 See more merch