unmemeful 

1 - someone or something that cannot meme and/or doesn't understand memes

2 - a distinct lack of "meme energy"

"Brenda is so unmemeful, all she sends to the group chat are minion memes"

unmemeful by Blank Latte June 21, 2021

unmemecultured

Lacking an understanding of currently used memes, mainly caused by differentiating senses of humor.

My friend showed me this meme someone posted the other day, and when I mentioned that I didn't understand what was funny about it, she called me unmemecultured.

unmemecultured by oikuzu October 14, 2018

unmemeducated 

When someone is uneducated on current day meme culture.

Oh my god, Becky is so unmemeducated, it's not even funny. She thinks that (*insert 2015 meme here) is still relevant.

unmemeducated by emmliz7310 June 13, 2017

ungameful 

to lack having game, to not come "correct"

Yo that nigga was mad ungameful.

ungameful by MeenaB October 27, 2008