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A person with two anus's. More commonly this is caused by an untreated anal cyst which breaks the skin and creates a second passage. There is another condition called genital duplication which is known to produce a second anus in sufferers.
A friend we once had apparently suffered from an anal cyst many years ago which created him a second anal passage.

Because we had no compassion for this person at all, we decided to call him twopoo - and so it was spoken, that from that day forward that anyone with the misfortune of having two arse holes would be known as a twopoo.
twopoo by Space Kat (=^.^=) June 29, 2007

twofootitus 

An infectious disease that starts with the purchase of your very first boat
Jimmy just bought a 17 foot boat. Now Jimmy is thinking that a 19 foot boat would be nice. Jimmy has twofootitus.
twofootitus by Rick Rasmussen January 19, 2008

twooodle 

a variation of one's own usual quite stable state of mind that may be upsetting for other people to experience whilst in your company, saying and doing things right out of character, swearing, shouting, blaming others, crying, unable to see reason...
jane went twooodle when she got upset about losing her position as the worlds number one mother.
twooodle by Jane G. July 30, 2007
Toopoo V.

To Toopoo a house or apartment; To take a shit and throw it on a house in place of toilet paper; Taking teepeeing a house to the next level.
Dude, I totally toopoo'd that house last night.

Let's go toopoo our teacher's apartment tonight!
Toopoo by Wreched June 28, 2009

twopointopian 

A derogatory term describing fanatics who enthusiastically support technology or philosophies described as "2.0" or "next generation."
Bob wants us to communicate via Twitter only. He's such a twopointopian!
twopointopian by chicken soprano January 12, 2009

twooo blooo

The word used by silly people on the discovery of two blue topped milk bottles during an early morning milk raid.
I got twooo blooo
twooo blooo by smoochbroch March 1, 2009