Two's up is a very old Yorkshire expression meaning, "Save me a small amount of what you're currently consuming" It was originally used by miners who were hungry and wanted a piece of pie from one of their more fortunate colleagues. It became more popular in the 70's and meant "share your cigarette with me".
by Little Alf September 08, 2016
by Phillian June 08, 2005
two's up is the act of slipping one in a lady friend whilst your friend does the same on another orifice
by nick williams January 12, 2009
by accadaccadefinitions April 16, 2010
by Dirty Sanchez December 13, 2003
by PVFC4EVER July 19, 2003