When a friend is telling a story that is supposed to be funny and entertaining but isn't quite that, you
say "Now, twist it funny." to declare to your friend that you will not carry on with the
conversation, untill a punchline has been
dropped.
That
guy: "As i was trekking through Nicaragua, heading towards a a childrens orphanage where I would deliver supplies, I met so many
interesting cultures that really helped shape me as a person, I feel
like i have changed in a profound way."
You yawn because you have heard this story too many times and responds. "Okay. Now, twist it funny." and sit back and enjoy the akward moment that ensues.