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Acronym for "testicle, left, suck it." Both the acronym and the statement itself should be used as a response similar to "suck my dick." If the full statement is used, it must be said slowly and with distinct pauses between each comma.
Nate: Yo, Jamal! You see all dem bitches I was wit last night?
Jamal: TLSI, Nate. TLSI.
TLSI by WilliamForrester August 27, 2011
Related Words
Too late seen it. often used online when someone links you to an image what you've already seen.
Guy1 "Hey dude check out this cool image"
guy2 "TLSI"
TLSI by Jezaroo_666 January 20, 2008

TSIWKBDWIMI 

the folder with a big name that you have to make in your email; "The Stuff I Wanna Keep But Don't Want In My Inbox"
I don't want this cluttering up in my Inbox, but I wanna keep it. I'll just move it to TSIWKBDWIMI.
TSIWKBDWIMI by Julia Sooch May 8, 2011