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Acronym for "testicle, left, suck it." Both the acronym and the statement itself should be used as a response similar to "suck my dick." If the full statement is used, it must be said slowly and with distinct pauses between each comma.
Nate: Yo, Jamal! You see all dem bitches I was wit last night?
Jamal: TLSI, Nate. TLSI.
by WilliamForrester August 25, 2011
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Too late seen it. often used online when someone links you to an image what you've already seen.
Guy1 "Hey dude check out this cool image"
guy2 "TLSI"
by Jezaroo_666 January 20, 2008
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