People that spend too much time in online worlds and virtual reality. Originates with the technology shown in the 1995 movie "Strange Days".
Uber drivers don't like it when squidheads be wire-trippin' on clips in the back of their limo.
by nobodyhuhuh March 23, 2013
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This one-liner may be used during an alien invasion, especially when you're a badass who is out to kill the beasts from outer space.

It is also possible to get the phrase as a dirty joke, according to the youtube celebrity Jesse Cox from the youtube channel "OMFGcata", who first came up with this sentence during his playthrough of the game "Crysis 2".
You kill an alien with your mere hands. You mention that you are choking a squidhead. You throw his corpse away.
by FancyTophatDude September 14, 2011
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