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Are your jimmies rustled? 

jimmies – feelings / thoughts / ego
rustled – hurt / disturbed
unrustled – peaceful / calm

As per Know Your Meme, the expression originated from 4chan in late 2010, and is used by trolls to "convey feelings of discontent or discomfort in response to someone else’s post in imageboards and discussion forums".

The expression is an alternate form of "u mad bro?".
Victim: What the heck is your problem!?
Troll: Are your jimmies rustled?
Victim: ...What is this I don't even
Troll: *trollface*

rustled my jimmies

as others have stated: something has angered, upset, annoyed, aroused you
this is more of a side note on origin - I suspect the phrase was a spontaneous misquote of a line from the Weezer song "Say It Ain't So" ("...flip on the telly/ wrestle with Jimmy...")
man, that pic was disgusting.
yeah, that one rustled my jimmies
rustled my jimmies by kingprout1 September 2, 2015

rustle jimmies 

The act of fucking up someone's shit to the point they can no longer continue to live with them selves because of how bad someone just ruined their day
"hey dj I did your girlfriend last night "

" what! No how could you rustle jimmies like that bro"
rustle jimmies by jebadiah wang February 24, 2014

Rustle My Jimmies 

“That Really Rustled My Jimmies” is an expression that is used to convey feelings of discontent or discomfort in response to someone else’s post in imageboards and discussion forums, most notably on 4chan. To rustle one's jimmies means to make someone discontent or to bother someone.
Man 1: "This guy is your boyfriend? He's worthless!"

Man 2: "That really does Rustle My Jimmies man..."
Rustle My Jimmies by Carlos-a-16 December 12, 2012

rustle your jimmies 

Stevens the type of guy to rustle your jimmies
rustle your jimmies by Clazza 1999 November 30, 2016

Whatever Rustles your Jimmies

Person 1: Hey man, what do you want to eat?
Person 2: Oh, I don't care. Whatever rustles your Jimmies.