To disturb someone by presenting them with facts/arguments that cause cognitive dissonance and challenge their views.
You know why people start arguments on the internet? Rustled jimmies man.
by CutFromAbove July 24, 2012
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The act of fucking up someone's shit to the point they can no longer continue to live with them selves because of how bad someone just ruined their day
"hey dj I did your girlfriend last night "

" what! No how could you rustle jimmies like that bro"
by jebadiah wang February 20, 2014
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“That Really Rustled My Jimmies” is an expression that is used to convey feelings of discontent or discomfort in response to someone else’s post in imageboards and discussion forums, most notably on 4chan. To rustle one's jimmies means to make someone discontent or to bother someone.
Man 1: "This guy is your boyfriend? He's worthless!"

Man 2: "That really does Rustle My Jimmies man..."
by Carlos-a-16 June 9, 2012
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Verb: To erk someone. To be all up in their biz. To cause frustration and anxiety. Basically to piss someone off in a profound way. Or, to bother someone's friends named jimmy
You: yo mama...
Me: I can't stand it when you rustle my jimmies like that

~or~
You: hey jimmy and jimmy. You suck
Me: Dude stop rustling my jimmies and apologize
by RustledJimmy January 14, 2016
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To bother or upset someone over a fairly trivial matter.
"have you been rustling someone's jimmies today?"

" yes, my friend got upset that I beat him yet again in monopoly"
by Soup dog March 15, 2015
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When something rustles your jimmies, it annoyed you or made you slightly angry.
Person 1: I can't believe Chipotle ran out of black beans!
Person 2: I know! That really rustles my jimmies.
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