Run this bitch Share definition Flag (v) - to dominate a situation; to have control on something or someone (syn): run this town Lacreesha: Would you like to take this outside? Kate: STEP THE FUCK BACK. I RUN THIS BITCH, HOE. Run this bitch by zzil October 28, 2010 0 0 Get merch Get the Run this bitch mug. Buy Now — $32.95 See more merch