To be in a dominating position where one has total or a large share of control over an industry,
business,
enterprise or most often a
drug spot.
1)
Chump: Yo look at that Escalade on 22s, that must be the cash money millionaires
Lil Nigga: Nah that's poppi, he runs shit down on 25th son
2)
"You think this is a joke motherfucker? I RUN shit, not you. The
game is MINE! (shoots competition in the
face)"