This is a word used by mallus or malayalees (people from the southern part of india)to describe the person they hate very much. It is equal to saying " son of a bitch" in English. This is considered of of the most rudest words in Malayalam.
A person whose emotional incompetency prohibits connection to furry creatures and/or cuddling furry creatures {eg. pandas}.
A friend syas to another: "Hey, the pandas are leaving; why isn't he crying?" "Oh, because he is a pandadouche, ie someone who doesnt cry when they have to leave the lil' nuggets."