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It means uncle, although in anime character regularly use it in its less formal form where it functions more as "mister" or "sir." It's just an informal, but not necessarily rude, way to refer to an older man than yourself that you're unfamiliar with.

That's all I wanted to get clear. Most definitions stop at uncle and barely explain the secondary, and probably more common, use for it. "Ojisan" always means "sir/mister" unless they're actually they're uncle.
"You dropped your wallet, Ojisan" = "You dropped your wallet, mister/sir."
Ojisan by i8toast7 November 16, 2018
Related Words
otisa OTIS Ojisan oyisa olisaemeka otigay Otised olisa Omisa orisa
a young goat and god who just chillin. Generally a lazy person but means well.
“Yo otusaku is a god!”
otusaku by User4337 July 5, 2020

otis redding 

general all-round dude, just an great singer. The sound of soul.
'it's been a long, long time comin', but i know a change is gonna come'
otis redding by Isabella18 June 27, 2006

olisaemeka 

is a smart, intelligent young man made to do great things in this world. He has the skills to be in a relationship since he was born.
I would want o name my child a olisaemeka
olisaemeka by O.K.N January 10, 2019
I word created by Oliver O’Neill meaning everything, don’t you dare steal his word. It means every single word ever so if someone asks if you are ok and you don’t know how to answer say omisaba.
Guy 1: Hey dude how are you feeling ?

Guy 2: Omisaba
Omisaba by Yellow tulip April 29, 2020
Outright blatant betrayal by someone you trust. Or casual use when promises are unfullfilled or you feel let down. (reference from The Walking Dead)
I can't believe you Otised me!
Otised by dr34m December 29, 2011