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It is rap-lingo for "nigga" or "nigger."
Its origin may be due to radio edits and censorship of certain words.
Gotta say what's up to my nizzo slick rick... for those dat don't like it, eat a dick.
nizzo by My nizzo June 18, 2004
1. An adjective synonomous with "extreme."
2. Crazy, very hardcore.
1. That bitch is nizzo nice.
2. That mufukka is going nizzo.
nizzo by dubz June 29, 2003
The man's got his hand up my nitty nizzo.
nizzo by L'il ignant dago November 8, 2003
Fo shizzo ma nizzo!
nizzo by Mike January 15, 2004
Usually an adjective, but can also be used as a noun. It can be used to describe almost anything in any way you want.
What's up, my nizzo. (What are you doing right now, my friend?)

Shit, nizzo, you wack. (Excuse me, Sir, but that was quite phallic of you.)
nizzo by Anonymous June 5, 2003

hell-to-the-nizzo 

Hell-To-The-No.
used when emphasizing that you are saying no

also:
hell to the:
nizzAW
nizzAY
"Let's hang out with eva CHURRO tonight!"
"hell-to-the-nizzo!!"