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Losers+Users. Originates from MIT. On their old mainframe systems, when you turned on a terminal it would say something like "57 users online". Someone hacked it to "losers", and someone hacked again to "lusers".
Welcome to the Network. 207 lusers online.
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Username:________
lusers by yu suk November 15, 2003
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Linux Users. More specifically, those morons that get off on coming after Windows users because they like using an operating system that is more complete and easier to use.
Duh! Windoze iz s0o l@me n' wind0z3 us3rz r such dumba$$es! What? Automatic installation of drivers for most hardware so you can use it quickly without having to dig around the internet for Linux versions so that you can use a simple device like a USB key? Why would I want that?! And why the fuck would I want virtually all commercial software to be compatable with my OS?
lusers by Fuck you, L-users May 13, 2005
People who haven't a clue and use computers
This one luser asked me how to copy a disk when she doesn't knwo how to fit two disks in the drive at once.
lusers by dislexus October 23, 2001
People who haven't a clue and use computers.
99.99% of all Windows users are lusers, why would they otherwise put up with such a substandard system if they didn't know better?
lusers by Mark July 31, 2003

Windows lusers 

Derogatory term used to address users of the Windows operating system
"this troll must be a windoze luser"
"dell is for windows lusers"
Windows lusers by Cantus November 4, 2002

WE ARE LOSERS 

A whole group of dope-ass losers
Somebody once told me that I was looking kinda dumb with my finger and my thumb in the shape of an ā€œLā€ on my forehead and asked if I was part of WE ARE LOSERS.

the losers club 

The Losers Club (aka TLC) first seen on Stephen King's IT.
Young Mike: Who are you guys anyway?
Young Eddie: We're sort of a club.
Young Bev: Yeah, the Losers Club.
Young Richie: Yeah.
Young Bill: You w-want in?
Young Mike: Yeah. Yeah, I do.
the losers club by cockersk August 25, 2013