Homie with an extra chromie 

Person with Down Syndrome, due to the fact the condition is caused by a person being born with 47 chromosomes instead of 46.

That guy with Down Syndrome is my Homie with an extra chromie.

Homie with an extra chromie by Golden Hawk April 13, 2023

homie with an extra chromie 

That one dude who you know has your back when that autism strikes.

Autistic Child #1: I'm gonna shoot up the school
Autistic Child #1: You cool though.
Me: You my homie with an extra chromie man.

homie with an extra chromie by Phiriz January 30, 2018