herpegonnosyphiltitis 

The most dreaded STD of all time...a combination of all possible diseases. Can only be contracted from the dirtiest whores in the world. Often used figuratively to emphasize the dirtiness of a person.

Art: "I hooked up with Lisa last night. It was awesome!"
Dave: "Oh yeah, that's what Sam, Johnny, Pete, Ted, Nick D..."
Art: "Wait...all those guys were up in that?"
Dave: "Yeah, and also Kevin, Matt, Will...shit I could go on forever."
Art: "So your telling me every guy in your frat has nailed this girl?"
Dave: "No, no, no, not at all. Only about 80% of my frat, I'd say. And pretty much all of SAE, Sigma Chi, Sigma Nu, Pike, Alpha Beta...but she's hot, man. Good job."
Art: "Is she clean?"
Dave: "No, she's got herpegonnosyphiltitis. You wrapped it up, right?"
Art: "So that's why my dick turned green and purple and rotted off this morning."
Dave: "Yeah, that explains it."

herpegonnosyphiltitis by Nick D July 13, 2004

herpegonnosyphiltitis 

It's supposed to be gonoherpesifilaids, tool.

That gutter-slut gave me gonoherpesifilaids.

herpegonnosyphiltitis by I'm Effin` AWESOME. June 1, 2005

herpegonosyphilitis

The worst of all sexually transmitted diseases. The herpes simplex virus with added genetic coding from the gonorrhea bacterium, allowing it to invade CD4+ T cells and rewrite their tRNA to code for syphilis proteins. Can only be cured by a cocktail of paracetamoxyfrusebendroneomycin and Mad Dog 20-20.

Guy 1: Dude, I think I caught herpegonosyphilitis from those 5 hookers at my party.
Guy 2: Here, have some paracetamoxyfrusebendroneomycin and a fifth of mad dog.

herpegonosyphilitis by Colonel Obvious February 21, 2009