Somewhat of a generic term to describe any ailment (typically gastrointestinal in nature) you may be having at the time. Often used in conjunction with "blowhole", as a combination that just sounds good together to complete the sentence.
Dude you don't look good..... you look like you're coming down with farfilosis.
It is said of the situation where a person has the bad luck to make contact with his testicles against an undefined surface or object, intentioned or not.
Given the nature of the word, it is more appropriate to design cases where the interaction is made with a moving object, for example, a ball.
Although it is extremely painful for the victim, it tends to be considerably funny to people who witness it.
Today in the baseball game the pitcher took a nutshot; the baseball hit him in the nuts.
Man, I just watched the funniest nutshot video ever.