duke-and-puke Share definition Flag an especially fowl bowel movement that triggers an immediate and uncontrolled spew, typically into a toilet-side trashcan. i must have eaten some bad tuna salad 'cause i had a duke-and-puke in the middle of the night. duke-and-puke by rickus July 25, 2006 0 0 Get merch Get the duke-and-puke mug. Buy Now — $32.95 See more merch
