A euphemism for ugly. A politically correct term similar to "mentally challenged", "vertically challenged", and "horizontally challenged". (Which meanretarded, short, and fat, respectively.
"In Washington D.C. and Santa Cruz, California, it's actually illegal to discriminate against people who are aesthetically challenged. Damn liberals..."
"I'm not ugly! I'm just *aesthetically challenged*!"
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.