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It is a midwestern diss, the equivalent of triple times greater then “buddy”, “lil bro” “jabroni”, and/or “cunt”

Insult must be said in an Italian accent.
Definition 1:

Pedro: Sorry I have to cancel on you tonight, I know we were gonna go bowling but I am taking a girl out to bowl instead tonight sorry buddy.

Jarquavis: What?!?! Are ya kidding me you are just gonna bail on me for a girl when we already had plans. You’re a simp ya fuckin “Zizipi”
Zizipi by noonybaby April 25, 2025
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A sweet girl and very happy sometimes a little stingy but lovable. Deep inside she's a very sweet girl who tries to make everyone happy but not so much herself she's wonderful ,beautiful and if you mess with her watch out!
"Did you see Zizipho i thought she so sweet but i saw her punch a guy "
zizipho by GirlMaster December 23, 2019
Related Words

Ziripipì 

Used in the area of Ascoli and Teramo to define a situation in which you have an argument with somebody because you disagree on a certain issue.
"I had a ziripipì with my son because he never obeys me"
Ziripipì by Vanbert91 June 1, 2017

Ziziaieiwieiriais 

Person A: I love Ziziaieiwieiriais
Ziziaieiwieiriais by .osqueaker October 23, 2022