t's a more 'polite' way of saying vafanculo, the Italian obscenity meaning "go do it in your ass". Vafanapoli means literally "go to Naples", with the implication being that everyone in Naples does it in the ass.
Jack: Mic, you are not strong enough.
Mic:That's not what your girlfriend said last night.
Jack: Vafanapoli!!!
A hardo is a person who tries extremely hard at everything. Most times a hardo will try very hard at things that do not require excessive effort. For example, sports practices, gym class, etc.
Wow did you see Jack at practice today? What a hardo!