The phenomenon in which someone seems far more attractive in the thumbnail version of a profile picture than they truly are.
I thought the girl who sent me a friend request was hot, but it turned out to be a case of Thumbnail Syndrome.
by Ken_II July 27, 2009
The kid next to me on the cross country bus trip was texting non stop for 7 hour; surely he has carpal thumbal syndrome by now.
by Steve Sherwood in Macon November 30, 2010
a medical condition resulting in numbness and possible paralysis in the thumbs and wrists from excessive texting or Blackberry use.
by Peeper1818 February 4, 2010