A state of intoxication which renders the drinker even more of a juvenile, self-centered, boorish dickhead than he was when sober. From tuckermax.com, a site dedicated to the puerile ramblings of a sickSOB.
You think I'm a total loser now? Wait 'til I get TMD on this half-gallon of vodka... then I'llreally be a complete fucking idiot.
Short-hand for the word floccinaucinihilipilification, meaning the estimation of something as valueless (encountered mainly as an example of one of the longest words in the English language).