Run one 

To play a single game of something, usually a pick-up sport.

*Sees three people sitting next to a basketball court*

"Aye, y'all tryna run one?"

ALTERNATIVELY

Friend: *Stares at your copy of Super Smash Bros sitting on the table*
You: "You tryna run one?"
Friend: "Run them hoes then!"

Run one by Yodaddybitch August 11, 2017

Run one 

He's got a gun. He's gonna fucking shoot you

"Na fuck that run one since you tough"

Run one by TipASnipper December 9, 2021

run one out

to spank it, masterbate.

sorry i was late - had to rub one out.

run one out by kevin barnard August 12, 2003

run one off 

To masturbate, usually referring to guys only. The term is used when a guy has the urge to whack it after seeing a hot girl.

I was dancing with this hot chick at the club, but I didn't go home with her. When I got home, I was so horny that I had to run one off.

run one off by RexGibson March 6, 2004

run one out

To kill kittens

run one out by Anonymous September 21, 2003

One-Run Stand 

Having sex once with someone you meet at a running event or race.

I met this chick yesterday at the race and after chowing down some free food, I had a one-run stand.

One-Run Stand by sixshooter April 6, 2010

Run me my one

Fight me right now

Aye I heard you was talking,I’m here now so run me my one

Run me my one by Lovebug02 May 28, 2018