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RUFS is short for "R U Fuckin Serious?!" Used for those occasions when "are you serious" is just not enough to question the seriousness of a situation.
For use as an exlamatory phrase, 'I was about to go dick deep in this bitch in the bathroom at da club until she opened her legs and it smelled like week old fish in a dumpster in the 100 degree sun and i was all like RUFS?!"
RUFS by JFBravo April 24, 2011
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In a moment of utter disbelief and there is no time to say the phrase "are you fucking serious!?!?"

Just say RUFS!?!

Can be used as a rhetorical question.

joking disbelief kidding lier unreal
RUFS by Zuzig September 7, 2013
Related Words
Are You Fuckin Serious. Used when an unblievable statement has been made in a chat room or on the street depending on who you are.
Mo: I hooked up with Renee 2day.

JayEm: OMFG
JayEm: RUFS

Jay: WTF
RUFS by Jay James July 2, 2003

James Joseph William Rufs 

James Joseph William Rufs is a god at fortnite: battle royal
Another name for Rohypnol, commonly known as the "date-rape drug" or a "roofie."
You should have just popped her a rufster and saved money on drinks.
rufster by LZtotheE July 28, 2007
Spin off on rufk. rufsrs = Are you fucking serious?
D3rekF1sherf4n: "Steve Nash isn't the best point guard in the NBA right now."
Non-retard: "RUFSRS!1one11!!!"
rufsrs by iamunoriginal December 15, 2009
Friend: we have a maths test today
Me: RUFSM
RUFSM by str33t July 13, 2012