"Pustulence" is a combination of 2 words (like "smog" is from "smoke" and "fog"). "Pestilence" (a devastating epidemic disease) plus "Pustulation" (the state of having pustules - pus-producing elevations of the skin).
In David Lynch's Dune, BaronVladimir Harkonnen found pleasure in his own pustulence.
12 step recovery jargon referring to someone new who talks about how great life is, now that they'resober. Usually meaning that the person is out of touch with reality.
The new guy seems pretty happy for a dude who has no job, no money and no family. He must be on a pink cloud.