Derived from the word Illuminati, it refers to a math elite that are increasingly controlling the future. One of the first people to popularize the phrase, "The Numerati" was the author and journalist, Stephen Baker, who also has a book of the same name.
Mark: What did you dolast night?
Me: I was still so hurt that Megan dumped me, that I got some serious numbnation in.
Mark: Hey, that helps ease the pain a little.