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Microwaving food for an extra long time to compensate for it being out of date and/or of questionable quality.
Dan:- "Is that pizza going to be ok? It's been there since Friday"

Matt:- "I'll nuke it to be sure"
Nuke it by Stern Boller August 5, 2011
To overly think a solution to any problem. Usually refer to and use by nuclear trained US Navy sailors.
Dude, don't nuke it. We just need directions to the store. We don't need exact GSP coordinates, altitude, and a bunch of other useless junk.
nuke it by T.X. Ryan July 12, 2007
to heat food in the microwave
"grab some tv dinner in the freezer and nuke it before you eat it"
nuke it by jveezy23 October 27, 2007
Hym "Nuke it? Yes. Not Japan though. Literally anywhere else. Perhaps Israel. Or a tree. Any random tree anywhere. I think it's been too long since we used them. But take Israel's nukes for KILLING CHILDREN WHICH WE PRETEND TO CARE SO MUCH ABOUT, don't actually care that much... Take their nukes and then nuke a tree. Any non-japan tree."
Nuke it? by Hym Iam October 17, 2025

nuke it from orbit 

One step up from kill it with fire, usually followed by the phrase "it's the only way to be sure."

A paraphrasal of Ripley's line in the 1986 film 'Aliens': "I say we take off and nuke the entire site from orbit. It's the only way to be sure."

Generally used in response to a clusterfuck, or anything largely weird or gross that needs killing or otherwise dealing with.
Mike: Guys, termites have invaded my house, what should I do?
Dave: Nuke it from orbit!
nuke it from orbit by mush01 August 27, 2008