Nuffis Share definition Flag To kick, knee, or punch someone in the crotch when they do/say something stupid. Person 1: "2+2=Vagina?" Person 2: "-nuffis-" Person 1: "-grabs crotch-" Nuffis by ommnommnomm September 3, 2010 0 0 Get merch Get the Nuffis mug. Buy Now — $32.95 See more merch