What happens to the palm of your hand after playing minigames in Mario Party that involve rotating the joy stick. Symptoms include soreness in the palm and/or a red mark where the joy stick was rotated.
After playing Mari Party for several hours, Jose began to experience Mario Party syndrome on his right hand.
by Itsa Mea Mario January 13, 2010
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The tendency to get sick of an extended game or movie marathon faster than you would if you were actually doing something for its regular duration.

Most often seen when someone suggests you play a 50 turn game of Mario Party, or all the tracks in a racing game, or watch all the extended versions of the LOTR.
"I'm already sick of this LOTR marathon"

"Dude, we haven't even gotten halfway through Fellowship yet. You're definitely suffering from "50 Turn Mario Party" syndrome."
by Anteaterking December 27, 2011
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