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Luke Disease is belittlement of the penis, erectile dysfunction, gayness and general rtardness. There is no known cure for this, sufferers are too rtarded and gay to accept a cure.
Known sufferers: Luke
Jole: "OMG, That My Rtarded friend was acting all gay today, and in the changing room, I saw his cock, it was the size of a PEA. He told me he had erectile dysfunction O_O"

DAVID: "OMFGZ, HE HAZ LUKE DISEASE!"
by Daemonius :] July 25, 2008
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2
the coolest disease to have. if you have it your awesome and every one wants it
"hes so cool" "yeah he has Luke disease"
by lukes bff June 06, 2018
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