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Inseminate is when a guy is fucking a girl in the vagina and then you hear: "OMG! OMG! OMG! OMG! *EXPLODE*"

Which means that the guy has blasted out all of his sperm into the girl's vagina over the course of about 30 seconds where the girl feels his hard dick pulsating rhythmically as his penis floods her vagina with each wave of semen that he's blowing out.
Girl to hot guy: "I want you to fuck me HARD! I don't want you to wear a condom and be all gentle the whole time like a prissy little bitch - I want you to FUCK ME LIKE A MAN! INSEMINATE ME! - I want every last drop of your sperm DEEP inside of me!"
by Penisboy123 December 31, 2010
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