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hyptonite 

Kryptonite for hipsters. Any previously obscure artistic entity that goes on to achieve mainstream acceptance, thereby rendering it irrelevant to hipsters, could be referred to as hyptonite.
James used to thoroughly enjoy Death Cab for Cutie, but he now claims that he never really cared for them. James must have been exposed to some serious hyptonite.
hyptonite by Chris Teja December 9, 2008
Related Words
When legs are so strong they can lift up cars.
"Dude your car has some sick hyponic legs."
hyponic by Headlong February 13, 2017