Hoe Nanny Share definition Flag Usually used between two girls. Similar to calling your friend a slut in a joking manner. pl:hoe nannies Girl 1: "Dude, those boys are so cute. I wanna hook up with that one" Girl 2: "You hoe nanny!" Hoe Nanny by Chris15988 December 30, 2008 Get the Hoe Nanny mug.