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1. literally meaning "herpes on the hands"

2. something you yell just cuz your belligerent and you like to cause a scene.
Catherine: "ew...she's gross"
Rene: "yeah, she's probably got that HERP ON THE HANDS!"

Catherine (belligerent): "HERP ON THE HANDS!!! MOFUGGA! HEHE HAHA"
by onecrazybeach April 29, 2011
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