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Gamer Thumb 

When you twerk the nipple so long that your thumb gets tired.
You better slow down baby, or you’re going to get gamer thumb.
Gamer Thumb by Sonofsaiyan October 6, 2020

Gamer's Thumb 

The condition of getting a sore/blistered thumb from playing video games for an extended amount of time.
"I played God of War II last night for five hours and i hadd to quit because i got gamer's thumb."
Gamer's Thumb by zits24 April 4, 2007

Gamer's Thumb 

The condition where a person's thumb becomes permanently disfigured due to playing video games, often results in a bump or oddly flat spot on the pads of both thumbs
Hey, my thumb has the weird flat spot on it. Oh, that's probably Gamer's Thumb
Gamer's Thumb by PriorDread December 13, 2013

Gamer's Thumb 

What happens when viral web sensation (and time traveling Mongolian warlord) hngryGenghis cuts off of his opponent's after he has beat them at a coin-op, console or PC video game.
I can't hitchhike anymore because I lost two times in a row to hngryGenghis and now I have a severe case of Gamer's Thumb.
Gamer's Thumb by hngryGenghis September 20, 2010

game thumb

What happens to your thumb after playing 2 or more consecutive hours of video games, especially games where you have to continuously tap buttons to get up and/or use the analog sticks.A blistered, red sensitive thumb. See nintendo thumb and playstation thumb.
If you play a Def Jam game, game thumb is a given. Bet on it.
game thumb by Nastina September 24, 2005

gamers thumb

where someone who has played videogames too much resulting in their thumb, when bent, has all their thumb padding near the joint where the analog stick would not be.
gamer: Hey dude, look at my thumb its like gone all retarded
friend: thats normal for a l33t gamer. Its called gamers thumb
gamer: really? will it be normal agian?
friend: no ur not a l33t gamer, and yeah ur stuck with it like that
gamers thumb by 2Ninja4U August 27, 2009