Game over, man! 

A phrase that means you've been caught by someone that you know will bring great suffering to you. Usually when you have an accomplice with you.

It's derived from a typical old school video game, as in "Game Over" = you lose. Coined by a couple of skits from "Robot Chicken"

Game over, man! GAME OVER!

Game over, man! by Rockin' Ruler of Metallic Meyhem June 20, 2007

Game over, man! 

Usually a screen after a game is over due to loss of all lives or failing a critical objective, especially in older (video) games.

It is conceding defeat, in this instance. Bill Paxton's Private Hudson famously says this line in ALIENS, after the drop ship coming to rescue him and his expedition crew crashes.

Private Hudson : (after the drop ship crash) Well, that's great. That's just fuckin' great, man! Now what the fuck are we supposed to do? We're in some real pretty shit now, man!

Corporal Hicks : (grabs him by the shirt) Are you finished?

Newt : I guess we're not gonna be leaving now, right?

Ripley : I'm sorry, Newt.

Newt : You don't have to be sorry. It wasn't your fault.

Private Hudson : That's it, man. Game over, man! Game over! What the fuck are we gonna do now? What are we gonna do?

Game over, man! by bimn May 5, 2019

Game Over, man! Game Over! 

What Hudson (The Ultimate Bad Ass) says after his Squads Evac Drop ship is taken down by the Xenomorphs. Spoken when your plan for an important mission fails horribly and then you end up pretty much boned.

Shit! I was going to bake some home made cookies but all I have is raisins.

Game over, man! Game over!

Game Over, man! Game Over! by MetaHybrid December 17, 2009