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Derpies is an increasingly prevalent socially-transmitted disease that impairs mental function in afflicted individuals. Derpies has become as common as one-in-two individuals on average in the world's population. The level of concentration of affected individuals increases the risk of exposure and transmission exponentially. Despite this fact, rural areas appear equally affected as urban areas. Cooperative vigilance and increased awareness are strongly advised as the only effective deterrents to the spread of this illness.

Symptoms of Derpies include:

Decline in common sense
Impairment of motor functions
Reduction in observational skills
Appreciation of reality television
Pattern of poor decisionmaking
Increased laugh response
Reckless driving and parking
Misuse of commonly used words
Distortion of spacial reasoning
Excessive quasi-aggressive
physical contact

If four or more of the listed symptoms apply to you, a friend or a loved one, Derpies may have already taken root in your social environment. Unlike its permanent, sexually-transmitted
cousin; Herpes, the non-permanent Derpies is potentially deadly. It is important for affected individuals to seek academic assistance immediately to mitigate Derpies-associated
risks to your social well-being.
Bob: "John has been acting ridiculously. He likes stupid things and laughs all the time."
Alice: "He has been hanging out with Frat boys."
Bob: "He has been watching the Jersey Shore reruns."
Alice: "We need to have an talk with him. I think that he has Derpies. And, I don't want to get it to."
Derpies by PacketLost August 6, 2015
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A disease (perhaps contagious) symptomized by using continuous "derp" actions.
"Man, I think Micheal has derpies."
"I know a few people who certainly have derpies."
Derpies by Lsh14 April 27, 2010
Related Words
A highly contagious disease originating from John Lane.
This disease is spread through acts of sheer stupidity, and there is no known cure.
Dammit, John touched me funny style and now I have da derpies
Derpies by RamstainAU September 26, 2010
(noun) 1. the unfortunate condition of permanent ugliness whose contorted nature is often misconstrued with the common phenomena of "herp-derping"
2. a title for someone who is often seen "herp-derping," whether in photographs or in real life
3. a good way to troll, or fool, others into admitting to embarrassing and most likely untrue diseases
1. Jake: "Dude, what's up with Todd's face?"
John: "I don't know man, he looks like he's herp-derping."
Todd: "Herrrrrrrrp, I have derpies."

2. Sam: "You ever notice how Todd is always derping in pictures?"
Chris: "Yeah, it's weird, I wonder if he has derpies."
Todd: "Herrrrrrrp, I have derpies."
Sam: "You don't say...."

3. Troll: "Herp, I have derpies."
Victim: "Oh yeah? Well, derp, I have herpies."
Crowd: "Booh!" "Get off the stage!"
Victim: "FFFFFFFFFFFUUUUUUUUUUUU...!"
Derpies by githeroter December 7, 2012
When your crabs have herpes.
Oh man that dude has a horrid case of derpies.
Derpies by LIONwho April 14, 2011
Derpies is an increasingly prevalent socially-transmitted disease that impairs mental function in afflicted individuals. Derpies has become as common as one-in-two individuals on average in the world's population. The level of concentration of affected individuals increases the risk of exposure and transmission exponentially. Despite this fact, rural areas appear equally affected as urban areas. Cooperative vigilance and increased awareness are strongly advised as the only effective deterrents to the spread of this illness.

Symptoms of Derpies include:

Decline in common sense
Impairment of motor functions
Reduction in observational skills
Appreciation of reality television
Pattern of poor decisionmaking
Increased laugh response
Reckless driving and parking
Misuse of commonly used words
Distortion of spacial reasoning
Excessive quasi-aggressive
physical contact

If four or more of the listed symptoms apply to you, a friend or a loved one, Derpies may have already taken root in your social environment. Unlike its permanent, sexually-transmitted
cousin; Herpes, the non-permanent Derpies is potentially deadly. It is important for affected individuals to seek academic assistance immediately to mitigate Derpies-associated
risks to your social well-being.
Bob: "John has been acting ridiculously. He likes stupid things and laughs all the time."
Alice: "He has been hanging out with Frat boys."
Bob: "He has been watching the Jersey Shore reruns."
Alice: "We need to have an talk with him. I think that he has Derpies. And, I don't want to get it to."
Derpies by PacketLost August 6, 2015

Herpa-Derpies 

A serious case of STS: Sexually Transmitted Stupid.
I heard Mary got drunk and had sex with her ex-boyfriend last night!" "Yeah, she has a bad case of herpa-derpies.
Herpa-Derpies by funthatburns March 2, 2011