To behave like a clown or jokester (a cut-up); to misbehave; to act in a playful, comical, boisterous, or unruly manner to elicit laughter, attention, etc.
ACTING sloppy/floored/trashed after a few drinks, generally to gain attention or try to seem cool. This often results in your bro's getting pissed.
Guy 1: Dude is Jay fucked up? We've been here for an hour.
Guy 2: Na dude, he's cuttin' up so hard. I watch that bitch have 3 beers and that's it.
Guy 1: Fuck him dude, we're not bringing him anymore. He's embarrassing as shit.
While our lifespan is the number of years we will live, our healthspan is the number of healthy years we will have and our sexspan is is the number of years we will continue to be healthy enough to continue having an active sex life.
A lighthearted reaction upon receiving disappointing news of some sort. Usually something that isn't a particularly a big deal, esp. when it primarily affects someone else - sort of a mild schadenfreude. Sometimes doubled or tripled, and possibly said in a sing-songy voice for added comedic effect to imitate a muted trumpet, which is how the meme originated.