When you lose weight, but your face looks like you have a disease.
That new diet made her body hot, but now she has cancer face.
by Dicwad January 16, 2016
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A severe chronic case of acne.
dude, that guy has a serious case of face cancer.
by lxpatterson June 8, 2007
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the prank in which one person tricks another by suggesting that if one's hand is bigger than their face, they have cancer. But upon placing their hand over their face, to test themselves out, the prankster smacks the person's hand into their own face.

*Origin: Unknown...does anyone know when this was created?
"Did you the Family Guy clip when Tom Tucker pulls that 'cancer of the face' prank on Diane Simmons during the Quahog News?"
by Little Big Daddy December 18, 2011
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A deragatory slang for elderly people especially if they have cancer
by Fortnite1500 November 7, 2021
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