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national e621 day, where all the furries collectively browse e621 at around 2 am.
furry 1: "Its 6/21!! You know what that means..."
furry 2: OwO
6/21 by bedsbee June 21, 2021
The furries si si no no day where they go on e621 and browse yiff
furry: the dates 6/21
furry 2: owo time for.. you know what ;)
a simple code to express extreme displeasure with someone. Alphabetic code numbered 1 to 26. In this case the illustrious F-U.
6-21 former coach of the red and gold California football team.

Hey, criminal elected leader of the free world, 6-21!
6-21 by Imtalkinhere December 18, 2014
When someone is being a cunt you can tell them 6-21. This is only to be used in a public setting where you can’t directly curse them out, and it stands for F-U, or (fuck you).
Person 1: Oh man it sure is great to see you!

Person 2: 6-21
6-21 by Ya boi Chris May 19, 2019
National Smoke Day. (Also known as the the Great American Smoke Out)

6/21 is the day you smoke all the Ganj you have.
Kid 1:6/21 is in two weeks!
Kid:2 Make sure we got lots of shit to smoke.
6/21 by Jae June 21, 2004
Its 6/21 so give sunsia a gift.
6/21 by thedevilher December 8, 2021