To hit someone, usually in the face. In this case, "block" is referring to a person's head and you are going to hit then so hard that there head would fall off if not attached!
If that dude over there wolf whistles at my girl again, I swear I'm going to go over and knock his block off
by IKnowTheLingo June 12, 2020
 Get the Knock His Block Offmug.
Get the Knock His Block Offmug. by Who are you? GTFO of here! July 17, 2014
 Get the knock your cock offmug.
Get the knock your cock offmug. I should never have been with him in the first place. He just didn’t knock my socks off  or anything.
by BrownSugar7 November 4, 2017
 Get the knock my socks offmug.
Get the knock my socks offmug. To knock someone off their feet is to be so impactful in someone's life, in typically a positive and affectionate way, that they are taken aback by the sudden force of their feelings for the person
by Ulo October 6, 2018
 Get the Knock her off her feetmug.
Get the Knock her off her feetmug.  Get the knock the dew off the lilymug.
Get the knock the dew off the lilymug. by Two-Ohh April 30, 2006
 Get the knock the checks off your nikesmug.
Get the knock the checks off your nikesmug. the ability to cause a stinch so profuse that the possibility of a buzzard being knocked off a shit wagon is actually thought of
by JKB March 12, 2004
 Get the knock a buzzard off a shit wagonmug.
Get the knock a buzzard off a shit wagonmug.