Knowing where to go. Having a sense of direction is like that giant finger on Simpsons Road Rage that points you to where you want to go, without even looking at a GPS.
You: "Hey Justin Bieber, where is the coffee shop?"
Justin: "And I was like, BABY! BABY! BABY OOOH!"
You: "Okay, I'll just use my Sense Of Direction.."
The inability to laugh, relax, take it easy, or find jokes funny. People with sense of humor cancer are typically perfectionists who never laugh. They can also appear as radical conservative assholes like Ann Coulter, or liberal hippie douchebags that have to defend everything. And if they smile at anything, it's the most vapid form of obvious humor. They take everything absolutely seriously and are usually an absolute buzzkill.
Sense of humor cancer can metastasize so badly that the victim may hate and be jealous of others who actually have a sense of humor.
"My sister lives in California, protests in demonstrations, hates all men, and never laughs at anything. I think she has sense of humor cancer."
A mental disorder shared largely by inner city residents. Symptoms usually include the following:
1: Usually desires to live month to month living off a welfare check without looking for work.
2: Usually panhandles around banks and downtown areas anyone they see (especially caucasians) for money under their warped belief that caucasians owe them everything for the past and present.
Very bad sense of humour. Juxtaposed to rhythm with tumour to give the sense of killing you with the bad jokes. Can only be used with close friends or with tumour patients who have a sense of humour and bad jokes in their kitty.