A command for someone to get lost (especially from the person that says it), usually as a result of extreme annoyance. Literally it means for them to masturbate themselves, so they aren't inclined to harrass and receive sexual pleasure from the person they are annoying. It's more stinging than "fuck off" because it implies that they could not or should not find anyone else to have sex with, so they need to use the self-manipulation.
How to say "go fuck yourself" but getting a better reaction out of the person and people around you. Unlike "go fuck yourself" Go fuck yourself with a screwdriver MUST be yelled as loudly as possible, even in a public place, no exceptions. This phrase may be used at any time, even when "go fuck yourself" normally wouldn't be used.
person1: So, I was thinking we could go out today an-
person2: GO FUCK YOURSELF WITH A RUSTY SCREWDRIVER!
everybody around them: 0_0
person1:0_0 dude wtf
Mostly said towards black people. If you are not black and the context isn't a hateful one, this can also be used ironically in a friendly conversation.
man 1: Have you met my sister?
man 2: More than met her, dude.
man 1: Go fuck yourself, nigger.
example 2:
man 1: go play another game you're so bad at this lol
man 2: Go fuck yourself nigger